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The IGF System

The IGF System PDF Author: Ron G. Rosenfeld
Publisher: Springer Science & Business Media
ISBN: 1592597122
Category : Medical
Languages : en
Pages : 788

Book Description
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

The IGF System

The IGF System PDF Author: Ron G. Rosenfeld
Publisher: Springer Science & Business Media
ISBN: 1592597122
Category : Medical
Languages : en
Pages : 788

Book Description
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

IGF and Nutrition in Health and Disease

IGF and Nutrition in Health and Disease PDF Author: M. Sue Houston
Publisher: Springer Science & Business Media
ISBN: 1592597955
Category : Medical
Languages : en
Pages : 359

Book Description
A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

The Role of the IGF System in Cancer, International Meeting

The Role of the IGF System in Cancer, International Meeting PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 2

Book Description


Ontogenetic development of the IGF-system and leptin in offspring of sows fed with gestation diets differing in protein content

Ontogenetic development of the IGF-system and leptin in offspring of sows fed with gestation diets differing in protein content PDF Author: Anika Steinhoff-Ooster
Publisher: Cuvillier Verlag
ISBN: 3736940610
Category : Science
Languages : en
Pages : 110

Book Description
The aim of this dissertation was to characterize leptin and the different components of the IGF-system in offspring of sows fed with different protein contents throughout pregnancy and to ascertain long term consequences caused by an inadequate nutritional environment in utero. German Landrace gilts (n=78) were fed gestation diets (~15.4 MJ ME/kg) of either low (LP, 6%; n=26), adequate (AP, 12%; n=26), or high (HP, 30%; n=24) protein content. For sampling at day 94 of gestation, 26 gilts with their fetuses were investigated. At parturition, the offspring of the remaining 52 gilts were cross fostered to nursing sows fed a standard lactation diet. Fetal and birth weight of all investigated offspring were recorded and classified into 2 different fetal body weight classes (Fbwc ≤ or > 0.65 kg) or birth weight classes (Bbwc ≤ or > 1.3 kg). In addition, the litter size of any gilt was classified into two groups (Lsgr ≤ or > 12 piglets). Blood and liver samples from 306 piglets in total were collected. In detail, fetuses of day 94 of gestation (dpc), and piglets at their 1st, 28th and 188th day of life (dpn) were sampled. Blood samples were assayed for IGF-1, IGF-2 and leptin by ELISA and for IGF binding proteins via a quantitative, non-radioactive Western ligand blotting protocol established and optimized herein. Liver samples were assayed for IGF-1 receptor by use of ELISA. The concentrations of leptin in offspring were not affected by maternal diet over all postnatal days. With the exception of dpn 1, the IGF-1 concentrations remained unchanged in response to maternal dietary treatment. Piglets born to mothers fed the LP diet had decreased IGF-1 concentrations compared to piglets born to HP mothers (P

The IGF System During Growth and Differentiation of the Mouse

The IGF System During Growth and Differentiation of the Mouse PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 168

Book Description


The IGF System During Growth and Differentiation of the Mouse

The IGF System During Growth and Differentiation of the Mouse PDF Author: Marjolein van Kleffens
Publisher:
ISBN:
Category :
Languages : en
Pages : 168

Book Description


The Insulin-like Growth Factor (IGF) System and Gastrointestinal Cancers

The Insulin-like Growth Factor (IGF) System and Gastrointestinal Cancers PDF Author: Sweet Lin Leng
Publisher:
ISBN:
Category : Colon (Anatomy)
Languages : en
Pages : 722

Book Description


IGF and Nutrition in Health and Disease

IGF and Nutrition in Health and Disease PDF Author: M. Sue Houston
Publisher: Humana
ISBN: 9781588291905
Category : Medical
Languages : en
Pages : 359

Book Description
A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.

Post-translational Modifications and Associations in the IGF System

Post-translational Modifications and Associations in the IGF System PDF Author: Olgica Nedic
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659192296
Category :
Languages : en
Pages : 156

Book Description
The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.

The Role of the Insulin-like Growth Factor (IGF) System in the Regulation of Ovine Placental and Fetal Growth

The Role of the Insulin-like Growth Factor (IGF) System in the Regulation of Ovine Placental and Fetal Growth PDF Author: Jane Claire Osgerby
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description